SPITZOID MELANOMA-CASE REPORT; POTENTIAL ROLE OF ALK EXPRESSION IN THE DIAGNOSIS OF SPITZOID MELANOCYTIC LESIONS

Patricia-Irina Stinga, Alina Stoica, Mirela Daniela Cioplea, Sabina-Andrada Zurac, Luciana Nichita, Cristina Gabriela Popp, Alexandra Ioana Cioroianu, Alexandra Eugenia Bastian

Abstract


Spitzoid neoplasms are classified as Spitz naevi, atypical Spitz tumours and spitzoid melanomas. In 10-15% of these lesions, anaplastic lymphoma kinase (ALK) fusions were identified, that can be demonstrated by immunohistochemical tests.

We report a case of spitzoid melanoma in a 15-year-old female patient. The tumor occurred as an un-ulcerated polypoid pigmented nodule
on the left thigh; the histopathologic examination revealed a spitzoid melanoma with Breslow index of 13 mm, with lympho-vascular invasion and immunohistochemical phenotype HMB45+, T311+, Melan A+, p16-, p21+, ALK-; sentinel lymph node biopsy identified three of four positive lymph nodes. The patient is well 20 months after the first diagnosis. 

Differential diagnosis in spitzoid melanoma is extremely difficult, no reliable biomarkers for treatment response prediction or prognosis being available to date.

Key words: Spitzoid neoplasm, ALK, Spitzoid melanoma. 

Cite this article:

Patricia-Irina Stîngă, Alina Stoica, Mirela Daniela Cioplea, Sabina-Andrada Zurac, Luciana Nichita, Cristiana Gabriela Popp,
Alexandra Ioana Cioroianu, Alexandra Eugenia Bastian. Spitzoid melanoma-case report; potential role of ALK expression in the diagnosis of spitzoid melanocytic lesions. RoJCED 2017;4(4):196-201. https://doi.org/10.26574/rojced.2017.4.4.196 



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