PEGYLATED LIPOSOMAL ENCAPSULATED DOXORUBICIN AND BRENTUXIMAB VEDOTIN IN STAGE IIB MYCOSIS FUNGOIDES – A CASE REPORT

Uwe Wollina, Gesina Hansel, Erich Zschuppe, Jacqueline Schönlebe

Abstract


Mycosis fungoides in advanced stages becomes a therapeutic challenge. During the course of the disease, the tumor may become treatment resistant. We report the use of pegylated liposomal encapsulated doxorubicin in a CD30-positive patient, who had become resistant to skin targeted PUVA treatment (psoralen plus UVA irradiation) and methotrexate. We achieved an objective global response lasting for seven months. Later on, the patient had a relapse and was no longer responding to doxorubicin, even with a dose escalation. A re-biopsy demonstrated the continuous expression of CD30, allowing a shift to CD-targeted treatment with brentuximab vedotine, a monoclonal antibody conjugate with monomethyl auristatin E. His objective global response lasted for six months, before he eventually deceased. CD30-targeted treatment is an option for mycosis fungoides with CD30 transformation. 

Key words: mycosis fungoides, CD30-transformation, pegylated liposomal encapsulated doxorubicin, brentuximab vedotine.

Cite this article:
Uwe Wollina, Gesina Hansel, Erich Zschuppe, Jacqueline Schönlebe. Pegylated liposomal encapsulated doxorubicin and brentuximab vedotin in stage IIB mycosis fungoides – case report. RoJCED 2017;3(4): 126-128. https://doi.org/10.26574/rojced.2017.4.3.126 

 


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