GLYCATION: IMPLICATION IN PERCEIVED AGE AND DERMATOLOGY

Victor Gabriel Clatici, Cristiana Voicu, Natalia Gennadievna Kalashnikova, Simona Fica

Abstract


Perceived age comprises different facial features and it is associated with multiple external factors, one of which is high levels of
serum glucose. Modern Western diet is associated with systemic elevated sugar levels. Excess sugars react with proteins, forming protein-bounded sugars involved in the process named glycation
and resulting in the formation of advanced glycation end products or AGEs. This article reviews the pathophysiological mechanisms involved in glycation and AGEs’ impact on tissues and organs of both healthy and diabetic individuals. Dietary advice must be an important part of medical consultation, emphasizing the benefits of a hypoglycemic diet. Future research aimed at discovering universal molecules that could interfere with AGE’s will be a major breakthrough in the management of diabetes and aging related conditions.

Key words: glycation, perceived age, sugar, sun, smoking, advanced glycation end products, diet.

Cite this article:

Victor Gabriel Clatici, Cristiana Voicu, Natalia Gennadievna Kalashnikova, Simona Fica. Glycation: implication in perceived age and dermatology.RoJCED 2017;3(4):114-123 https://doi.org/10.26574/rojced.2017.4.3.114 



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